Effect of Curcumin on Apoptosis and Proliferation of Human Hepatocellular Carcinoma WCH-17 Cell Line

Masumeh Sanaei, Fraidoon Kavoosi

Abstract


Hepatocellular carcinoma (HCC) is the most common cancer of the liver and the 5th commonest malignancy and also the third leading cause of cancer related death worldwide. Herbal medicines have an important role to prevent cancer. Curcumin is the herbal and dietary spice turmeric with diverse pharmacologic effects including antiproliferative, antiangiogenic and anti-cancer properties. The aim of the present study was to analyze the effect of curcumin on cell growth and apoptosis in the hepatocellular carcinoma WCH-17 cell line. Materials and Methods: MTT assay and flow cytometry assay were used to evaluate proliferative and apoptotic effect of curcumin on WCH-17 cell line. Results: curcumin inhibited the growth of WCH-17 cell and induced apoptosis significantly with a time- and dose-dependent manner. Discussion: Our finding clearly indicated that curcumin has a significant inhibitory and apoptotic effect. Conclusion: curcumin can significantly inhibit the growth of WCH-17 cell and play a significant role in apoptosis.


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